Article
Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P. falciparum Malaria.
mBio - 28 Jun 2022
Ray Ananya, Mathur Miti, Choubey Deepak, Karmodiya Krishanpal, Surolia Namita
Abstract excerpt
Emerging resistance to artemisinin (ART) has become a challenge for reducing worldwide malaria mortality and morbidity. The C580Y mutation in Plasmodium falciparum Kelch13 has been identified as the major determinant for ART resistance in the background of other mutations, which include the T38I mutation in autophagy-related protein PfATG18. Increased endoplasmic reticulum phosphatidylinositol-3-phosphate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.