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Article

Apicoplast ribosomal protein S10-V127M enhances artemisinin resistance of a Kelch13 transgenic Plasmodium falciparum.

Malaria journal - 27 Oct 2022

Kampoun Tanyaluck, Srichairatanakool Somdet, Prommana Parichat, Shaw Philip J, Green Judith L, Knuepfer Ellen, Holder Anthony A, Uthaipibull Chairat

Abstract excerpt

BACKGROUND: The resistance of Plasmodium falciparum to artemisinin-based (ART) drugs, the front-line drug family used in artemisinin-based combination therapy (ACT) for treatment of malaria, is of great concern. Mutations in the kelch13 (k13) gene (for example, those resulting in the Cys580Tyr [C580Y] variant) were identified as genetic markers for ART-resistant parasites, which suggests they are associated with...

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PMID: 36303209
DOI: 10.1186/s12936-022-04330-3
PMCID: PMC9615251

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