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Article

Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral Infection

2025-03-11

Abstract excerpt

Interferon Regulatory Factor 7 (IRF7), and its homologue IRF3, are master transcriptional regulators of the innate immune response. IRF7 binds to promoters of interferon β (IFNβ) and several IFNαs as a homodimer or as a heterodimer with IRF3 to drive expression of these type I IFNs, which in turn activate downstream signaling pathways to promote expression of antiviral genes. Here we demonstrate that alternative s...

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Identifiers and source

Literature Corpus work
9adccae0-4d35-53f6-aa6f-fa36c94f175c
DOI
10.1101/2025.03.10.642367
Open publication

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Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral InfectionDOI 10.1101/2025.03.10.642367
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