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Article

Review: Nuclear/Cytoplasmic Localization of IRFs in Response to Viral Infection or Interferon Stimulation

1 Jan 2002

Abstract excerpt

Members of the interferon (IFN) regulatory factor (IRFs) family of transcription factors play diverse roles in immunity and cellular response to viral infections. Their biologic effects result from their ability to regulate either constitutive, inducible, or tissue-specific gene expression. All characterized IRFs contain nuclear localization signals that allow their translocation to the nucleus. However, certain...

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PMID: 11846981
DOI: 10.1089/107999002753452719

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