Article

Regulation of human interferon signaling by transposon exonization

2023-09-15

Abstract excerpt

<h4> <h4>Summary: </h4> </h4> Innate immune signaling is essential for clearing pathogens and damaged cells, and must be tightly regulated to avoid excessive inflammation or autoimmunity. Here, we found that the alternative splicing of exons derived from transposable elements is a key mechanism controlling immune signaling in human cells. By analyzing long-read transcriptome datasets, we identified numerous tran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7706cb47-79d2-5ad9-ae19-aeddfbe278b3
DOI: 10.1101/2023.09.11.557241

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of human interferon signaling by transposon exonizationDOI 10.1101/2023.09.11.557241Read

Regulation of human interferon signaling by transposon exonizationSemantic proximity Read

Antiviral immunity triggered by infection-induced host transposable elementsSemantic proximity Read

Impaired activation of Transposable Elements in SARS-CoV-2 infectionSemantic proximity Read

Virus-induced transposable element expression up-regulation in human and mouse host cellsSemantic proximity Read

Evolutionary arms race between transposable elements and human genes: telomere-to-telomere genome comprehensive analysis identifies young L1 clusters in the interferon-alpha domainSemantic proximity Read

Cell-Specific Transposable Element Gene Expression Analysis Identifies Associations with Systemic Lupus Erythematosus PhenotypesSemantic proximity Read

Sensing of transposable elements by the antiviral innate immune systemSemantic proximity Read

Impaired activation of transposable elements in SARS‐CoV‐2 infectionSemantic proximity Read

'There and back again': revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era.Semantic proximity Read

Retrotransposon life cycle and its impacts on cellular responsesSemantic proximity Read

Endogenous Retroviruses as Modulators of Innate ImmunitySemantic proximity Read

SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elementsSemantic proximity Read