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Article

Non-transcriptional IRF7 interacts with NF-κB to inhibit viral inflammation.

The Journal of biological chemistry - 1 Apr 2024

Fan Shumin, Popli Sonam, Chakravarty Sukanya, Chakravarti Ritu, Chattopadhyay Saurabh

Abstract excerpt

Interferon (IFN) regulatory factors (IRF) are key transcription factors in cellular antiviral responses. IRF7, a virus-inducible IRF, expressed primarily in myeloid cells, is required for transcriptional induction of interferon α and antiviral genes. IRF7 is activated by virus-induced phosphorylation in the cytoplasm, leading to its translocation to the nucleus for transcriptional activity. Here, we revealed a...

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Coronavirus Infections
HEK293 Cells
Inflammation
Murine hepatitis virus
NF-kappa B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factor RelA

Virus Replication

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Identifiers

PMID: 38508315
DOI: 10.1016/j.jbc.2024.107200
PMCID: PMC11040127

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