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Article

Global and Distinct Targets of IRF-5 and IRF-7 during Innate Response to Viral Infection

12 Aug 2004

Abstract excerpt

The interferon regulatory factors (IRF) are transcriptional mediators of cellular response to viral invasion that play a critical role in the innate antiviral defense. Two of these factors, IRF-5 and IRF-7, play a critical role in the induction of interferon (IFNA) genes in infected cells; they are expressed constitutively in monocytes, B cells, and precursors of dendritic cells (pDC2) that are high producers of...

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PMID: 15308637
DOI: 10.1074/jbc.m400726200

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