Article

Interferon-γ Elicits Pathological Hallmarks of ALS in Human Motor Neurons

2022-11-19

Abstract excerpt

Neuroinflammation is an established factor contributing to amyotrophic lateral sclerosis (ALS) pathology, implicating the possible detrimental effects of inflammatory cytokines on motor neurons. The RNA/DNA-binding protein TDP-43 has emerged as a pivotal actor in ALS, because TDP-43 mutations cause familial ALS and loss of nuclear TDP-43, associated with its redistribution into cytoplasmic aggregates (TDP-43 prote...

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Literature Corpus work: 9947827d-28cb-5d66-b951-22e63f70f216
DOI: 10.1101/2022.11.18.517141

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