Article
Genome-wide autozygosity is associated with lower general cognitive ability.
Molecular psychiatry - 1 Jun 2016
Howrigan D P, Simonson M A, Davies G, Harris S E, Tenesa A, Starr J M, Liewald D C, Deary I J, McRae A, Wright M J, Montgomery G W, Hansell N, Martin N G, Payton A, Horan M, Ollier W E, Abdellaoui A, Boomsma D I, DeRosse P, Knowles E E M, Glahn D C, Djurovic S, Melle I, Andreassen O A, Christoforou A, Steen V M, Hellard S L, Sundet K, Reinvang I, Espeseth T, Lundervold A J, Giegling I, Konte B, Hartmann A M, Rujescu D, Roussos P, Giakoumaki S, Burdick K E, Bitsios P, Donohoe G, Corley R P, Visscher P M, Pendleton N, Malhotra A K, Neale B M, Lencz T, Keller M C
Abstract excerpt
Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among outbred populations, autozygosity can occur to varying degrees due to cryptic relatedness between parents. Using dense...
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