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Genetics of consanguinity and inbreeding in health and disease

28 Nov 2016

Abstract excerpt

CONTEXT: Inbreeding increases the level of homozygotes for autosomal recessive disorders and is the major objective in clinical studies. The prevalence of consanguinity and the degree of inbreeding vary from one population to another depending on ethnicity, religion, culture and geography. Global epidemiological studies have revealed that consanguineous unions have been significantly associated with increased...

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PMID: 27892699
DOI: 10.1080/03014460.2016.1265148

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