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Article

NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation.

Nature communications - 27 Apr 2016

Frank René A W, Komiyama Noboru H, Ryan Tomás J, Zhu Fei, O'Dell Thomas J, Grant Seth G N

Abstract excerpt

How neuronal proteomes self-organize is poorly understood because of their inherent molecular and cellular complexity. Here, focusing on mammalian synapses we use blue-native PAGE and 'gene-tagging' of GluN1 to report the first biochemical purification of endogenous NMDA receptors (NMDARs) directly from adult mouse brain. We show that NMDARs partition between two discrete populations of receptor complexes and...

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Identifiers

PMID: 27117477
DOI: 10.1038/ncomms11264
PMCID: PMC5227094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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