Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Protein Biochemistry of the Postsynaptic Density in Glutamatergic Synapses Mediates Learning in Neural Networks.

Biochemistry - 10 Jul 2018

Kennedy Mary B

Abstract excerpt

The strength of each excitatory synapse in the central nervous system is regulated by its prior activity in a process called synaptic plasticity. The initiation of synaptic plasticity occurs when calcium ions enter the postsynaptic compartment and encounter a subcellular structure called the postsynaptic density (PSD). The PSD is attached to the postsynaptic membrane just underneath the concentrated plaque of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glutamic Acid
Share to Long-Term Potentiation
Share to Mental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Nerve Net

Share to Nerve Tissue Proteins

Share to Neurodegenerative Diseases

Share to Neuronal Plasticity

Source

Open in PubMed Open full text

Identifiers

PMID: 29913061
DOI: 10.1021/acs.biochem.8b00496
PMCID: PMC7879948

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Protein Biochemistry of the Postsynaptic Density in Glutamatergic Synapses Mediates Learning in Neural Networks.PMID 29913061Read ↗

Proteomics of brain synapses and molecular dissection of synaptic subdomains.Semantic proximity Read ↗

Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking.Semantic proximity Read ↗

Analysis of proteins in computational models of synaptic plasticitySemantic proximity Read ↗

Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation.Semantic proximity Read ↗

Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice.Semantic proximity Read ↗

Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95Semantic proximity Read ↗

Occurrence of ordered and disordered structural elements in postsynaptic proteins supports optimization for interaction diversitySemantic proximity Read ↗

Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms.Semantic proximity Read ↗

Release your inhibitions: The cell biology of GABAergic postsynaptic plasticitySemantic proximity Read ↗

Synaptopathies: diseases of the synaptome.Semantic proximity Read ↗

Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease.Semantic proximity Read ↗

Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.