Back to search

Article

Generation of a Three-dimensional Human Neurovascular Unit Model in a Microfluidic Chip

2025-04-19

Abstract excerpt

<h4>Background</h4> The well-functioning of the neurovascular unit (NVU) is supported by the 3D brain physiological microenvironment that allows for extensive neural-neural and neural-vascular interactions. This microenvironment is normally hard to create in traditional in-vitro models such as the transwell model. Organ-on-a-chip (OOC) emerges as advanced model systems by providing better physiological microenvi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5e5638c5-fc13-5f11-b06a-34cc8d53ce10
DOI
10.1101/2025.04.13.648605
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Generation of a Three-dimensional Human Neurovascular Unit Model in a Microfluidic ChipDOI 10.1101/2025.04.13.648605
3D brain angiogenesis model to reconstitute maturation of functional human blood-brain barrier <i>in vitro</i>Semantic proximity
Vascular-Perfusable Human 3D Brain-on-ChipSemantic proximity
<i>On-chip</i> perivascular niche with patient-derived glioma cellsSemantic proximity
Multicellular Organoids of the Neurovascular Blood-Brain Barrier: A New Platform for Precision NeuronanomedicineSemantic proximity
Three-dimensional induced pluripotent stem-cell models of human brain angiogenesisSemantic proximity
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvesselsSemantic proximity
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvesselsSemantic proximity
Three-Dimensional Cultures for Collecting CNS and PNS Glial Secreted Factors, Vesicles and Scaffolds Free of Animal Serum ComponentsSemantic proximity
The Shift from 2D to 3D Cell Culture in Neurobiology: Implications for Precision Medicine and Organ-on-Chip TechnologiesSemantic proximity
Three-dimensional induced pluripotent stem-cell models of human brain angiogenesisSemantic proximity
Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture modelSemantic proximity
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling propertiesSemantic proximity
Select a neighboring publication to make it the new centre.