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Article

Long-Term Cryopreservation Preserves Blood-Brain Barrier Phenotype of iPSC-Derived Brain Microvascular Endothelial Cells and Three-Dimensional Microvessels.

Molecular pharmaceutics - 8 Sept 2020

Linville Raleigh M, DeStefano Jackson G, Nerenberg Renée F, Grifno Gabrielle N, Ye Robert, Gallagher Erin, Searson Peter C

Abstract excerpt

Brain microvascular endothelial cells derived from induced pluripotent stem cells (dhBMECs) are a scalable and reproducible resource for studies of the human blood-brain barrier, including mechanisms and strategies for drug delivery. Confluent monolayers of dhBMECs recapitulate key in vivo functions including tight junctions to limit paracellular permeability and efflux and nutrient transport to regulate...

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Identifiers

PMID: 32787285
DOI: 10.1021/acs.molpharmaceut.0c00484
PMCID: PMC9923881

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