Article

<i>APOE</i> ε4 effects on hippocampal atrophy in the healthy elderly reflect future cognitive decline

2022-01-14

Abstract excerpt

The APOE ε4 allele is the primary genetic risk factor for late onset Alzheimer’s disease (AD). A cardinal problem in determining APOE ε4’s effect on cognition and brain structure in older individuals is dissociating prodromal changes – linked to increased AD risk – from potential phenotypic differences. To address this, we used cognitive and neuroimaging data from a large cohort of cognitively normal 69-86 year-...

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Literature Corpus work: 9a65bbb5-eaa9-51a4-9efb-a7cef6e9672d
DOI: 10.1101/2022.01.07.475319

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