Article

Nuclear effects play an important role in determining codon usage-dependent human gene expression

2024-10-23

Abstract excerpt

Codon usage biases play a significant role in determining gene expression levels. Codon usage was thought to primarily influence translation-dependent processes. Here we show that codon usage optimality correlates genome-wide with nuclear mRNA and transcription levels in human cells, suggesting a nuclear role for codon usage. A genome-wide non-biased CRISPR-Cas9 screen was performed to identify factors involved in...

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Literature Corpus work: 9a1ce7d3-5b4e-53b2-afe1-a12c1e3ad111
DOI: 10.1101/2024.10.20.619315

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