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Efflux pump antibiotic binding site mutations are associated with azithromycin nonsusceptibility in clinical <i>Neisseria gonorrhoeae</i> isolates

2020-06-04

Abstract excerpt

Lyu and Moseng et al. used cryo-electron microscopy to characterize key residues involved in drug binding by mosaic-like MtrD efflux pump alleles in Neisseria gonorrhoeae (1). Isogenic experiments introducing key MtrD substitutions R714G and K823E increased macrolide MICs, leading the authors to predict that non-mosaic MtrD “gonococcal strains bearing both the mtrR promoter and amino acid changes at MtrD positio...

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Literature Corpus work
9a18876b-0d96-506d-a2c5-c2cf0c353354
DOI
10.1101/2020.06.03.132159
Open publication

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Efflux pump antibiotic binding site mutations are associated with azithromycin nonsusceptibility in clinical <i>Neisseria gonorrhoeae</i> isolatesDOI 10.1101/2020.06.03.132159
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