Article
Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance.
Antimicrobial agents and chemotherapy - 20 Jan 2021
Pham Cau D, Nash Evelyn, Liu Hsi, Schmerer Matthew W, Sharpe Samera, Woods Grace, Roland Brad, Schlanger Karen, St Cyr Sancta B, Carlson Jonathan, Sellers Kevin, Olsen Aaron, Sanon Ruth, Hardin Henrietta, Soge Olusegun O, Raphael Brian H, Kersh Ellen N
Abstract excerpt
A2059G mutation in the 23S rRNA gene is the only reported mechanism conferring high-level azithromycin resistance (HL-AZMR) in Neisseria gonorrhoeae Through U.S. gonococcal antimicrobial resistance surveillance projects, we identified four HL-AZMR gonococcal isolates lacking this mutational genotype. Genetic analysis revealed an A2058G mutation of 23S rRNA alleles in all four isolates. In vitro selected...
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