Article

Functional and structural characterization of H105Y mutation in MtrR protein of <i>Neisseria gonorrhoeae</i>

2020-07-08

Abstract excerpt

MtrR is a negative regulator of MtrCDE efflux pump. Various N-Terminal and C-Terminal mutations have been reported in different multidrug resistant clinical isolates of Neisseria gonorrhoeae across the world. Mutations in N-terminal region of MtrR, are known to abrogate its binding with the promoter thereby providing an evidence that this region encodes for DNA binding domain. In contrast, mechanism of action of...

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Literature Corpus work: ca965e48-20b4-569e-8324-79d1155f5226
DOI: 10.1101/2020.07.07.192807

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