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Mechanistic basis for decreased antimicrobial susceptibility in a clinical isolate of <i>Neisseria gonorrhoeae</i> possessing a mosaic-like <i>mtr</i> efflux pump locus

2018-10-22

Abstract excerpt

Recent reports suggest that mosaic-like sequences within the mtr ( m ultiple t ransferable r esistance) efflux pump locus of Neisseria gonorrhoeae likely originating from commensal Neisseria sp. by transformation can increase the ability of gonococci to resist structurally diverse antimicrobials. Thus, acquisition of numerous nucleotide changes within the mtrR gene encoding the transcriptional repressor (Mt...

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Literature Corpus work
04d3da8d-a369-5223-9fb7-527c7a0a9d3b
DOI
10.1101/448712
Open publication

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Mechanistic basis for decreased antimicrobial susceptibility in a clinical isolate of <i>Neisseria gonorrhoeae</i> possessing a mosaic-like <i>mtr</i> efflux pump locusDOI 10.1101/448712
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