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Article

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae.

mBio - 7 Aug 2018

Wadsworth Crista B, Arnold Brian J, Sater Mohamad R Abdul, Grad Yonatan H

Abstract excerpt

Mosaic interspecifically acquired alleles of the multiple transferable resistance (mtr) efflux pump operon correlate with increased resistance to azithromycin in Neisseria gonorrhoeae in epidemiological studies. However, whether and how these alleles cause resistance is unclear. Here, we use population genomics, transformations, and transcriptional analyses to dissect the relationship between variant mtr alleles...

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Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Expression Regulation, Bacterial

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Share to Membrane Transport Proteins

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Share to Transformation, Bacterial

Source

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Identifiers

PMID: 30087172
DOI: 10.1128/mBio.01419-18
PMCID: PMC6083905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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