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Article

Molecular pathways to high-level azithromycin resistance in Neisseria gonorrhoeae.

The Journal of antimicrobial chemotherapy - 18 Jun 2021

Laumen J G E, Manoharan-Basil S S, Verhoeven E, Abdellati S, De Baetselier I, Crucitti T, Xavier B B, Chapelle S, Lammens C, Van Dijck C, Malhotra-Kumar S, Kenyon C

Abstract excerpt

BACKGROUND: The prevalence of azithromycin resistance in Neisseria gonorrhoeae is increasing in numerous populations worldwide. OBJECTIVES: To characterize the genetic pathways leading to high-level azithromycin resistance. METHODS: A customized morbidostat was used to subject two N. gonorrhoeae reference strains (WHO-F and WHO-X) to dynamically sustained azithromycin pressure. We tracked stepwise evolution of...

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Anti-Bacterial Agents
Azithromycin
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neisseria gonorrhoeae

RNA, Ribosomal, 23S

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PMID: 33760080
DOI: 10.1093/jac/dkab084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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