Article
Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.
Nucleic acids research - 19 Apr 2021
Beggs Grace A, Ayala Julio C, Kavanaugh Logan G, Read Timothy D, Hooks Grace M, Schumacher Maria A, Shafer William M, Brennan Richard G
Abstract excerpt
Mutations within the mtrR gene are commonly found amongst multidrug resistant clinical isolates of Neisseria gonorrhoeae, which has been labelled a superbug by the Centers for Disease Control and Prevention. These mutations appear to contribute to antibiotic resistance by interfering with the ability of MtrR to bind to and repress expression of its target genes, which include the mtrCDE multidrug efflux...
Topics
- Bacterial Proteins
- Binding Sites
- DNA, Bacterial
- Drug Resistance, Multiple, Bacterial
- Gene Expression Regulation, Bacterial
- Mutation
- Neisseria gonorrhoeae
- Protein Binding
- Repressor Proteins