Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efflux Pump Antibiotic Binding Site Mutations Are Associated with Azithromycin Nonsusceptibility in Clinical Neisseria gonorrhoeae Isolates

24 Aug 2020

Abstract excerpt

Lyu and Moseng et al. used cryo-electron microscopy to characterize key residues involved in drug binding by mosaic-like MtrD efflux pump alleles in Neisseria gonorrhoeae (1). Isogenic experiments introducing key MtrD substitutions R714G and K823E increased macrolide MICs, leading the authors to predict that nonmosaic MtrD “gonococcal strains bearing both the mtrR promoter and amino acid changes at MtrD positions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Infections and Vaccines
Share to Clostridium difficile and Clostridium perfringens research
Share to Reproductive tract infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32843551
DOI: 10.1128/mbio.01509-20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efflux Pump Antibiotic Binding Site Mutations Are Associated with Azithromycin Nonsusceptibility in Clinical Neisseria gonorrhoeae IsolatesPMID 32843551Read ↗

Efflux pump antibiotic binding site mutations are associated with azithromycin nonsusceptibility in clinical <i>Neisseria gonorrhoeae</i> isolatesSemantic proximity Read ↗

Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin.Semantic proximity Read ↗

Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux PumpsSemantic proximity Read ↗

Mechanistic basis for decreased antimicrobial susceptibility in a clinical isolate of <i>Neisseria gonorrhoeae</i> possessing a mosaic-like <i>mtr</i> efflux pump locusSemantic proximity Read ↗

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump LocusSemantic proximity Read ↗

Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.Semantic proximity Read ↗

Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae.Semantic proximity Read ↗

Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016Semantic proximity Read ↗

The Synergistic Armory: A Global Genome-Wide Association Study Reveals the Integrated Mechanisms of Azithromycin Resistance in Neisseria gonorrhoeae.Semantic proximity Read ↗

Increased antibiotic susceptibility in <i>Neisseria gonorrhoeae</i> through adaptation to the cervical environmentSemantic proximity Read ↗

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae.Semantic proximity Read ↗

Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.