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Article

Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania.

Malaria journal - 1 Dec 2015

Hansson Helle Holm, Turner Louise, Møller Line, Wang Christian William, Minja Daniel T R, Gesase Samwel, Mmbando Bruno, Bygbjerg Ib Christian, Theander Thor G, Lusingu John P A, Alifrangis Michael, Lavstsen Thomas

Abstract excerpt

BACKGROUND: Endothelial protein C receptor (EPCR) was recently identified as a key receptor for Plasmodium falciparum erythrocyte membrane protein 1 mediating sequestration of P. falciparum-infected erythrocytes in patients suffering from severe malaria. Soluble EPCR (sEPCR) inhibits binding of P. falciparum to EPCR in vitro and increased levels of sEPCR have been associated with the H3 haplotype of the EPCR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26620701
DOI: 10.1186/s12936-015-1007-6
PMCID: PMC4666078

Genes

PROCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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