The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria.

doi:10.1038/srep27084

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The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria.

Scientific reports - 3 Jun 2016

Shabani Estela, Opoka Robert O, Bangirana Paul, Park Gregory S, Vercellotti Gregory M, Guan Weihua, Hodges James S, Lavstsen Thomas, John Chandy C

Abstract excerpt

The endothelial protein C receptor (EPCR) appears to play an important role in Plasmodium falciparum endothelial cell binding in severe malaria (SM). Despite consistent findings of elevated soluble EPCR (sEPCR) in other infectious diseases, field studies to date have provided conflicting data about the role of EPCR in SM. To better define this role, we performed genotyping for the rs867186-G variant, associated...

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PMID: 27255786
DOI: 10.1038/srep27084
PMCID: PMC4891778

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