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Article

Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria.

Malaria journal - 17 Mar 2014

Naka Izumi, Patarapotikul Jintana, Hananantachai Hathairad, Imai Hiroo, Ohashi Jun

Abstract excerpt

BACKGROUND: Cytoadhesion of Plasmodium falciparum-infected erythrocytes to endothelial cells in microvessels is a remarkable characteristic of severe malaria. The endothelial protein C receptor (EPCR), encoded by the endothelial protein C receptor gene (PROCR), has recently been identified as an endothelial receptor for specific P. falciparum erythrocyte membrane protein 1 (PfEMP1) subtypes containing domain...

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Identifiers

PMID: 24635948
DOI: 10.1186/1475-2875-13-105
PMCID: PMC4004250

Genes

PROCR

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