Article

Probabilistic Fine-mapping of Putative Causal Genes

2024-10-29

Abstract excerpt

Integrative genetic analysis of molecular and complex trait data, including colocalization analysis and transcriptome-wide association studies (TWAS), has shown promise in linking GWAS findings to putative causal genes (PCGs) underlying complex diseases. However, existing methods have notable limitations: TWAS tend to produce an excess of false-positive PCGs, while colocalization analysis often lacks sufficient st...

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Literature Corpus work: 9a0b5260-a5db-518d-985d-e3aca0744698
DOI: 10.1101/2024.10.27.620482

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