Article

Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation

2019-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Influenza A viruses have regularly jumped to new hosts to cause epidemics or pandemics, an evolutionary process that involves variation in the viral traits necessary to overcome host barriers and facilitate transmission. Mice are not a natural host for influenza virus, but are frequently used as models in studies of pathogenesis, often after multiple passages to achieve higher viral titers that...

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Literature Corpus work: 9a00cc22-ecb0-5e45-9c9c-d4865394aee9
DOI: 10.1101/683516

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