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Influenza A viruses serially passaged in different MDCK cell lines exhibit limited sequence variation across their genomes, with the exception of the hemagglutinin gene

2020-02-23

Abstract excerpt

<h4>ABSTRACT</h4> New methods for deep sequence analysis provide an opportunity to follow the emergence and dynamics of virus mutations in real time. Although viruses are commonly grown in cell culture for research and for vaccine development, the cells used to grow the virus are often not derived from the same tissue or even the same host that the virus naturally replicates in. The selective pressures of culturi...

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Literature Corpus work
ab348eb1-c6b9-511e-b526-1a3f7a3c2d77
DOI
10.1101/2020.02.20.959015
Open publication

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Influenza A viruses serially passaged in different MDCK cell lines exhibit limited sequence variation across their genomes, with the exception of the hemagglutinin geneDOI 10.1101/2020.02.20.959015
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