Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Internal gene segments from a mouse-adapted influenza B virus confer increased pathogenicity to mice.

PloS one - 1 Jan 2026

Matthys Arne, Amelinck Laura, Smet Anouk, Ysenbaert Tine, Vogel Thorsten U, Saelens Xavier, Portela Catani João Paulo

Abstract excerpt

Influenza B viruses (IBVs) contribute significantly to the annual influenza epidemics in human. Most IBV strains are non- or poorly pathogenic in mice, which are frequently used for vaccine studies. We describe the generation of a mouse-adapted IBV strain that retains pathogenicity in mice when carrying hemagglutinin (HA) and neuraminidase (NA) gene segments from a heterologous IBV strain. Serial passage of an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dogs
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza B virus

Share to Madin Darby Canine Kidney Cells

Share to Neuraminidase

Share to Orthomyxoviridae Infections

Share to Reassortant Viruses

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41871085
DOI: 10.1371/journal.pone.0335324
PMCID: PMC13008076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Internal gene segments from a mouse-adapted influenza B virus confer increased pathogenicity to mice.PMID 41871085Read ↗

Multi-segment mouse-adaptation of a recent B/Victoria-lineage virus independent from hemagglutinin and neuraminidaseSemantic proximity Read ↗

Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion ProductionSemantic proximity Read ↗

A Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses.Semantic proximity Read ↗

Mouse adaptation of influenza B virus increases replication in the upper respiratory tract and results in droplet transmissibility in ferrets.Semantic proximity Read ↗

Altered virulence of Highly Pathogenic Avian Influenza (HPAI) H5N8 reassortant viruses in mammalian modelsSemantic proximity Read ↗

Analysis by Single-Gene Reassortment Demonstrates that the 1918 Influenza Virus Is Functionally Compatible with a Low-Pathogenicity Avian Influenza Virus in MiceSemantic proximity Read ↗

Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus.Semantic proximity Read ↗

Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutationsSemantic proximity Read ↗

The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation.Semantic proximity Read ↗

Multiple adaptive amino acid substitutions increase the virulence of a wild waterfowl-origin reassortant H5N8 avian influenza virus in mice.Semantic proximity Read ↗

Expanding Mouse-Adapted Yamagata-like Influenza B Viruses in Eggs Enhances In Vivo Lethality in BALB/c MiceSemantic proximity Read ↗

PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.