Article
Deep sequencing reveals the viral adaptation process of environment-derived H10N8 in mice.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2016
Mei Kun, Liu Guang, Chen Zhenzhen, Gao Zhimin, Zhao Lihua, Jin Tao, Yu Xiaolan, Chen Quanjiao
Abstract excerpt
The H10N8 virus was isolated from the water of Dongting Lake, China. Mice were infected while showing no obvious symptoms and replication was restricted to the lungs. When the wild-type virus was serially passaged in the lungs of mice, the resulting viruses became lethal and capable of replication in many other organs. This offered an applicable model for the exploration of viral genome gradual mutation during...
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