Article

Temporal tissue dynamics from a spatial snapshot

2024-04-26

Abstract excerpt

Physiological and pathological processes such as inflammation or cancer emerge from the interactions between cells over time. However, methods to follow cell populations over time within the native context of a human tissue are lacking, because a biopsy offers only a single snapshot. Here we present one-shot tissue dynamics reconstruction (OSDR), an approach to estimate a dynamical model of cell populations based...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99ef15f6-b904-5c37-9cb7-4392d3790a3f
DOI: 10.1101/2024.04.22.590503

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Temporal tissue dynamics from a spatial snapshotDOI 10.1101/2024.04.22.590503Read

Adaptive Digital Tissue DeconvolutionSemantic proximity Read

Spatial organization and stochastic fluctuations of immune cells impact clinical responsiveness to immune checkpoint inhibitors in patients with melanomaSemantic proximity Read

Spatiotemporal regulation of cell cycle states within the complex tumor microenvironmentSemantic proximity Read

SpaFlow depicts the dynamics of ligand-receptor interaction in spatial transcriptomics dataSemantic proximity Read

Single-cell morphodynamical trajectories enable prediction of gene expression accompanying cell state changeSemantic proximity Read

Reconstructing True 3D Spatial Omics at Single-Cell ResolutionSemantic proximity Read

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosuresSemantic proximity Read

Instant fluorescence lifetime imaging microscopy reveals mechano-metabolic reprogramming of stromal cells in breast cancer peritumoral microenvironmentsSemantic proximity Read

VIP-OT: Dissecting Single-Cell Biochemical State Dynamics under Perturbation via Vibrational Painting and Optimal TransportSemantic proximity Read

Single cell imaging-based chromatin biomarkers for tumor progression.Semantic proximity Read

A high-resolution single-nucleus RNA sequencing reveals conserved macrophage activation trajectories across muscle regeneration and dystrophy.Semantic proximity Read

Live-seq enables temporal transcriptomic recording of single cells.Semantic proximity Read