Article

Single-cell morphodynamical trajectories enable prediction of gene expression accompanying cell state change

2024-01-20

Abstract excerpt

Extracellular signals induce changes to molecular programs that modulate multiple cellular phenotypes, including proliferation, motility, and differentiation status. The connection between dynamically adapting phenotypic states and the molecular programs that define them is not well understood. Here we develop data-driven models of single-cell phenotypic responses to extracellular stimuli by linking gene transcrip...

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Literature Corpus work: ec2b17b3-9736-5c0a-975e-c429ae4eed34
DOI: 10.1101/2024.01.18.576248

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