Article

Spatiotemporal regulation of cell cycle states within the complex tumor microenvironment

2025-12-02

Abstract excerpt

Tumor growth and resistance arise from the interplay between cell-cycle dysregulation and the spatial organization of the tumor microenvironment (TME). While spatial transcriptomics now enables molecular profiling of intact tissues, it captures only static molecular states, making it challenging to reconstruct dynamic processes such as proliferation. Here, we develop SpaceCycle, a computational framework that infe...

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Identifiers and source

Literature Corpus work: 6ce1cfec-80cc-5262-ab1a-d5fe4a6ba117
DOI: 10.64898/2025.11.28.691200

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