Article

Reconstructing True 3D Spatial Omics at Single-Cell Resolution

2026-05-01

Abstract excerpt

Capturing the three-dimensional (3D) organization of cells is essential for deciphering complex biological processes, yet comprehensive 3D spatial omics is severely hindered by the destructive nature of physical sectioning and the depth limitations of intact tissue imaging. Current computational methods rely on 2.5D stacking of discrete slices, which inherently disrupts tissue topology and fails to resolve continu...

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Literature Corpus work: 47d93f0f-440e-5835-ac6c-e70d7163d083
DOI: 10.64898/2026.04.28.721395

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