Article

Target-dependent siRNA suppression distinguishes self from non-self endogenous siRNAs in <i>C. elegans</i> germline

2022-01-26

Abstract excerpt

Despite their prominent role in transposon silencing, expression of endo-siRNAs is not limited to the “non-self” DNA elements. Transcripts of protein-coding genes (“self” DNA) in some cases also produce endo-siRNAs in yeast, plants, and animals [1]. How cells distinguish these two populations of siRNAs to prevent unwanted silencing of self-genes in animals is not well understood. To address this question, we exami...

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Literature Corpus work: 99b0be5e-b98e-55f3-8ae5-d64b020f04db
DOI: 10.1101/2022.01.25.477739

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