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Article

Nuclear RNAi contributes to the silencing of off-target genes and repetitive sequences in Caenorhabditis elegans.

Genetics - 1 May 2014

Zhou Xufei, Xu Fei, Mao Hui, Ji Jiaojiao, Yin Meng, Feng Xuezhu, Guang Shouhong

Abstract excerpt

Small RNAs recognize, bind, and regulate other complementary cellular RNAs. The introduction of small RNAs to eukaryotic cells frequently results in unintended silencing of related, but not identical, RNAs: a process termed off-target gene silencing. Off-target gene silencing is one of the major concerns during the application of small RNA-based technologies for gene discovery and the treatment of human disease....

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Identifiers

PMID: 24532782
DOI: 10.1534/genetics.113.159780
PMCID: PMC4012473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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