Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells.

Science (New York, N.Y.) - 23 May 2008

Ghildiyal Megha, Seitz Hervé, Horwich Michael D, Li Chengjian, Du Tingting, Lee Soohyun, Xu Jia, Kittler Ellen L W, Zapp Maria L, Weng Zhiping, Zamore Phillip D

Abstract excerpt

Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA (dsRNA) as a defense against viral infection. We identified endogenous siRNAs (endo-siRNAs), 21 nucleotides in length, that correspond to transposons and heterochromatic sequences in the somatic cells of Drosophila melanogaster. We also detected endo-siRNAs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Argonaute Proteins
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Retroelements

Share to Ribonuclease III

Share to RNA, Double-Stranded

Share to RNA Helicases

Share to RNA-Induced Silencing Complex

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 18403677
DOI: 10.1126/science.1157396
PMCID: PMC2953241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells.PMID 18403677Read ↗

Transposon defense by endo-siRNAs, piRNAs and somatic pilRNAs in Drosophila: contributions of Loqs-PD and R2D2.Semantic proximity Read ↗

A distinct small RNA pathway silences selfish genetic elements in the germline.Semantic proximity Read ↗

Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines.Semantic proximity Read ↗

Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.Semantic proximity Read ↗

Limited impact of the siRNA pathway on transposable element expression in <i>Aedes aegypti</i>Semantic proximity Read ↗

Mechanistic divergence of piRNA biogenesis in DrosophilaSemantic proximity Read ↗

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.Semantic proximity Read ↗

Target-dependent siRNA suppression distinguishes self from non-self endogenous siRNAs in <i>C. elegans</i> germlineSemantic proximity Read ↗

Divergent regulatory impacts of endogenous siRNAs on host mRNAs in testis of closely related speciesSemantic proximity Read ↗

Quantitatively increased somatic transposition of transposable elements in Drosophila strains compromised for RNAi.Semantic proximity Read ↗

Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.Semantic proximity Read ↗

Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.