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Article

Function, targets, and evolution of Caenorhabditis elegans piRNAs.

Science (New York, N.Y.) - 3 Aug 2012

Bagijn Marloes P, Goldstein Leonard D, Sapetschnig Alexandra, Weick Eva-Maria, Bouasker Samir, Lehrbach Nicolas J, Simard Martin J, Miska Eric A

Abstract excerpt

Piwi-interacting RNAs (piRNAs) are small RNAs required to maintain germline integrity and fertility, but their mechanism of action is poorly understood. Here we demonstrate that Caenorhabditis elegans piRNAs silence transcripts in trans through imperfectly complementary sites. Target silencing is independent of Piwi endonuclease activity or "slicing." Instead, piRNAs initiate a localized secondary endogenous...

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Identifiers

PMID: 22700655
DOI: 10.1126/science.1220952
PMCID: PMC3951736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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