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PML plays both inimical and beneficial roles in HSV-1 replication

9 May 2016

Abstract excerpt

After entry into the nucleus, herpes simplex virus (HSV) DNA is coated with repressive proteins and becomes the site of assembly of nuclear domain 10 (ND10) bodies. These small (0.1-1 μM) nuclear structures contain both constant [e.g., promyelocytic leukemia protein (PML), Sp100, death-domain associated protein (Daxx), and so forth] and variable proteins, depending on the function of the cells or the stress to...

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PMID: 27162364
DOI: 10.1073/pnas.1605513113

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