Article
Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1.
PLoS pathogens - 1 May 2020
Paulus Christina, Harwardt Thomas, Walter Bernadette, Marxreiter Andrea, Zenger Marion, Reuschel Edith, Nevels Michael M
Abstract excerpt
Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and innate antiviral defense. The eponymous PML proteins, central to the self-organization of PML bodies, and other restriction factors found in these organelles are common targets of viral antagonism. The 72-kDa immediate-early protein 1 (IE1) is the principal antagonist of PML bodies encoded by the human cytomegalovirus (hCMV)....
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