Article

Role of PML-Nuclear Bodies in Human Herpesvirus 6A and 6B Genome Integration

2018-09-10

Abstract excerpt

Human herpesviruses 6A and 6B (HHV-6A/B) are two betaherpesviruses that readily integrate their genomes into the telomeres of human chromosomes. To date, the cellular or viral proteins that facilitate HHV-6A/B integration remain elusive. In the present study, we demonstrate that the immediate early protein 1 (IE1) of HHV-6A/B colocalizes with telomeres during infection. Moreover, IE1 associates with PML-NBs, a nuc...

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Literature Corpus work: 1ab2ae4c-19dc-5d51-8120-57584fcb6815
DOI: 10.1101/413575

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