Article
TCR usage, gene expression and function of two distinct FOXP3(+)Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO.
Immunology and cell biology - 1 Mar 2016
Ye Lingying, Goodall Jane C, Zhang Libin, Putintseva Ekaterina V, Lam Brian, Jiang Lei, Liu Wei, Yin Jian, Lin Li, Li Ting, Wu Xin, Yeo Giles, Shugay Mikhail, Chudakov Dmitriy M, Gaston Hill, Xu Huji
Abstract excerpt
FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expression of FOXP3 by activated effector cells. Here, we report that expression of CD39 and CD45RO distinguishes three sub-populations within human CD4(+)CD25(hi) T cells....
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