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Article

Phenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential.

Cellular and molecular life sciences : CMLS - 12 Sept 2024

Kattelus Roosa, Starskaia Inna, Lindén Markus, Batkulwar Kedar, Pietilä Sami, Moulder Robert, Marson Alexander, Rasool Omid, Suomi Tomi, Elo Laura L, Lahesmaa Riitta, Buchacher Tanja

Abstract excerpt

Regulatory T cells (Tregs) play a key role in suppressing systemic effector immune responses, thereby preventing autoimmune diseases but also potentially contributing to tumor progression. Thus, there is great interest in clinically manipulating Tregs, but the precise mechanisms governing in vitro-induced Treg (iTreg) differentiation are not yet fully understood. Here, we used multiparametric mass cytometry to...

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Identifiers

PMID: 39264416
DOI: 10.1007/s00018-024-05429-3
PMCID: PMC11393232

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