Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delineating phenotypic heterogeneity in human regulatory T cells across developmental stages and therapeutic sources.

Frontiers in immunology - 1 Jan 2026

Santosh Nirmala Samikshya, Hu Yueyuan, Floegel Friederike Dorothea, Cruz Hugo, Morgenstern Johanna, Platz Alexander, Vollroth Marcel, Fuchs Anke

Abstract excerpt

Background: FOXP3+ regulatory T cells (Tregs) play a pivotal role in maintaining immune homeostasis and self-tolerance. Despite advances in Treg-based immunosuppressive therapies, precise identification of human Tregs facilitating their isolation with high purity remains challenging because canonical markers such as FOXP3 and CD25 are also induced in activated CD4+ effector T cells (Teffs). This study aims to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Blood

Share to Flow Cytometry

Share to Forkhead Transcription Factors

Share to Immunophenotyping

Share to T-Lymphocytes, Regulatory

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 41659850
DOI: 10.3389/fimmu.2026.1697723
PMCID: PMC12872549

Genes

FOXP3
CD4
TIGIT
GPA33
CD226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delineating phenotypic heterogeneity in human regulatory T cells across developmental stages and therapeutic sources.PMID 41659850Read ↗

Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.Semantic proximity Read ↗

Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.Semantic proximity Read ↗

Defining Human Regulatory T Cells beyond FOXP3: The Need to Combine Phenotype with Function.Semantic proximity Read ↗

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.Semantic proximity Read ↗

Phenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential.Semantic proximity Read ↗

Deep sequencing of the TCR-β repertoire of human forkhead box protein 3 (FoxP3)+ and FoxP3- T cells suggests that they are completely distinct and non-overlapping.Semantic proximity Read ↗

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host diseaseSemantic proximity Read ↗

Hiding in Plain Sight: CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissuesSemantic proximity Read ↗

Maturation and Phenotypic Heterogeneity of Human CD4+ Regulatory T Cells From Birth to Adulthood and After Allogeneic Stem Cell Transplantation.Semantic proximity Read ↗

Transcriptomic Profiling of Human Effector and Regulatory T Cell Subsets Identifies Predictive Population SignaturesSemantic proximity Read ↗

Regulatory T-Cell Development in the Human ThymusSemantic proximity Read ↗

Transcriptomic profiling of human effector and regulatory T cell subsets identifies predictive population signaturesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.