Article

Forward genetics combined with unsupervised classifications identified zebrafish mutants affecting biliary system formation

2021-06-23

Abstract excerpt

Impaired formation of the biliary network can lead to congenital cholestatic liver diseases; however, the genes responsible for proper biliary system formation and maintenance have not been fully identified. Combining computational network structure analysis algorithms with a zebrafish forward genetic screen, we identified 24 new zebrafish mutants that display impaired intrahepatic biliary network formation. Compl...

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Literature Corpus work: 1971db3f-4726-57f0-8b5c-e3cafb8bb535
DOI: 10.1101/2021.06.22.449425

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