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Article

A globin-family protein, Cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish.

Developmental biology - 1 Apr 2021

Takahashi Kazuki, Ito Yuki, Yoshimura Mami, Nikaido Masataka, Yuikawa Tatsuya, Kawamura Akinori, Tsuda Sachiko, Kage Daichi, Yamasu Kyo

Abstract excerpt

The zebrafish is an excellent model animal that is amenable to forward genetics approaches. To uncover unknown developmental regulatory mechanisms in vertebrates, we conducted chemical mutagenesis screening and identified a novel mutation, kanazutsi (kzt). This mutation is recessive, and its homozygotes are embryonic lethal. Mutant embryos suffered from a variety of morphological defects, such as head flattening,...

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Identifiers

PMID: 33358912
DOI: 10.1016/j.ydbio.2020.12.016

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