Article

Tafazzin-Deficient Zebrafish Display Mitochondrial Dysfunction, Neutropenia, and Metabolic Defects Without Myopathy

2025-04-24

Abstract excerpt

<title>Abstract</title> <p>Barth syndrome is an X-linked syndrome characterized by cardiomyopathy, skeletal myopathy, and neutropenia. This life-threatening disorder results from loss-of-function mutations in <italic>TAFAZZIN</italic>, which encodes a phospholipid-lysophospholipid transacylase located in the mitochondria inner membrane. Decreased cardiolipin levels and increased monolysocardiolipin levels perturb...

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Literature Corpus work: 2a640c15-d691-5953-be75-fe6e0eb43c16
DOI: 10.21203/rs.3.rs-5960642/v1

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