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Article

Generation and validation of a myoglobin knockout zebrafish model.

Transgenic research - 1 Dec 2023

Hejlesen Rasmus, Kjær-Sørensen Kasper, Fago Angela, Oxvig Claus

Abstract excerpt

Previous studies using myoglobin (Mb) knockout mice and knockdown zebrafish have presented conflicting results about in vivo phenotypes resulting from the loss of this conserved and highly expressed protein, and therefore a new well-characterized knockout model is warranted. We here describe the generation of three distinct zebrafish mb knockout lines using the CRISPR/Cas system. None of the three lines exhibited...

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PMID: 37847464
DOI: 10.1007/s11248-023-00369-3
PMCID: PMC10713697

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